pre-B cell colony-enhancing factor,PBEF - PMC

Published in final edited form as: Cytokine Growth Factor Rev. 2013 Oct; 24(5): 433–442. Published online 2013 Jun 17. doi: 10.1016/j.cytogfr.2013.05.006

PMCID:: PMC3791181

Abstract Article PDF–501K

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Neuronal protective role of PBEF in a mouse model of cerebral ischemia

Weiping Zhang, Yicheng Xie, Tiannan Wang, Jing Bi, Hailong Li, Li Qin Zhang, Shui Qing Ye, Shinghua Ding

J Cereb Blood Flow Metab. 2010 Dec; 30(12): 1962–1971. Published online 2010 May 19. doi: 10.1038/jcbfm.2010.71

PMCID:: PMC3002881

Abstract Article PDF–772K

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Extracellular nicotinamide phosphoribosyltransferase: role in disease pathophysiology and as a biomarker

Elise Semerena, Alessio Nencioni, Krzysztof Masternak

Front Immunol. 2023; 14: 1268756. Published online 2023 Oct 17. doi: 10.3389/fimmu.2023.1268756

PMCID:: PMC10616597

Abstract Article PDF–2.5M

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Extracellular nicotinamide phosphoribosyltransferase, a new cancer metabokine

Ambra A Grolla, Cristina Travelli, Armando A Genazzani, Jaswinder K Sethi

Br J Pharmacol. 2016 Jul; 173(14): 2182–2194. Published online 2016 Jun 2. doi: 10.1111/bph.13505

PMCID:: PMC4919578

Abstract Article PDF–980K

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Nicotinamide Phosphoribosyltransferase Inhibitor Is a Novel Therapeutic Candidate in Murine Models of Inflammatory Lung Injury

Liliana Moreno-Vinasco, Hector Quijada, Saad Sammani, Jessica Siegler, Eleftheria Letsiou, Ryan Deaton, Laleh Saadat, Rafe S. Zaidi, Joe Messana, Peter H. Gann, Roberto F. Machado, Wenli Ma, Sara M. Camp, Ting Wang, Joe G. N. Garcia

Am J Respir Cell Mol Biol. 2014 Aug; 51(2): 223–228. doi: 10.1165/rcmb.2012-0519OC

PMCID:: PMC4148034

Abstract Article PDF–1.4M

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Nicotinamide phosphoribosyltransferase (Nampt): A link between NAD biology, metabolism, and diseases

Shin-ichiro Imai

Curr Pharm Des. Author manuscript; available in PMC 2009 Aug 28.

Published in final edited form as: Curr Pharm Des. 2009; 15(1): 20–28. doi: 10.2174/138161209787185814

PMCID:: PMC2734389

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Targeting Nicotinamide Phosphoribosyltransferase as a Potential Therapeutic Strategy to Restore Adult Neurogenesis

Shu‐Na Wang, Tian‐Ying Xu, Wen‐Lin Li, Chao‐Yu Miao

CNS Neurosci Ther. 2016 Jun; 22(6): 431–439. Published online 2016 Mar 28. doi: 10.1111/cns.12539

PMCID:: PMC6492912

Abstract Article PDF–277K

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Visfatin: A Possible Role in Cardiovasculo-Metabolic Disorders

Ali Dakroub, Suzanne A. Nasser, Nour Younis, Humna Bhagani, Yusra Al-Dhaheri, Gianfranco Pintus, Assaad A. Eid, Ahmed F. El-Yazbi, Ali H. Eid

Cells. 2020 Nov; 9(11): 2444. Published online 2020 Nov 9. doi: 10.3390/cells9112444

PMCID:: PMC7696687

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Nicotinamide Phosphoribosyltransferase Purification Using SUMO Expression System

Trivikram R. Molugu, Radu C. Oita, Udeep Chawla, Sara M. Camp, Michael F. Brown, Joe G. N. Garcia

Anal Biochem. Author manuscript; available in PMC 2020 Dec 14.

Published in final edited form as: Anal Biochem. 2020 Jun 1; 598: 113597. Published online 2020 Jan 23. doi: 10.1016/j.ab.2020.113597

PMCID:: PMC7735423

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Inhibition of Pre-B Cell Colony Enhancing Factor Reduces Lung Injury in Rats Receiving Cardiopulmonary Bypass

Chao Lu, Wei Yang, Jianliang Zhou, Zulei Zhang, Yi Gong, Fajia Hu, Wenpeng Yu, Xiao Dong

Drug Des Devel Ther. 2021; 15: 51–60. Published online 2021 Jan 7. doi: 10.2147/DDDT.S281554

PMCID:: PMC7800440

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Proinflammatory Actions of Visfatin/Nicotinamide Phosphoribosyltransferase (Nampt) Involve Regulation of Insulin Signaling Pathway and Nampt Enzymatic Activity

Claire Jacques, Martin Holzenberger, Zvezdana Mladenovic, Colette Salvat, Emilie Pecchi, Francis Berenbaum, Marjolaine Gosset

J Biol Chem. 2012 Apr 27; 287(18): 15100–15108. Published online 2012 Mar 7. doi: 10.1074/jbc.M112.350215

PMCID:: PMC3340217

Abstract Article PDF–889K

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Unique Toll-Like Receptor 4 Activation by NAMPT/PBEF Induces NFκB Signaling and Inflammatory Lung Injury

Sara M. Camp, Ermelinda Ceco, Carrie L. Evenoski, Sergei M. Danilov, Tong Zhou, Eddie T. Chiang, Liliana Moreno-Vinasco, Brandon Mapes, Jieling Zhao, Gamze Gursoy, Mary E. Brown, Djanybek M. Adyshev, Shahid S. Siddiqui, Hector Quijada, Saad Sammani, Eleftheria Letsiou, Laleh Saadat, Mohammed Yousef, Ting Wang, Jie Liang, Joe G. N. Garcia

Sci Rep. 2015; 5: 13135. Published online 2015 Aug 14. doi: 10.1038/srep13135

PMCID:: PMC4536637

Abstract Article PDF–2.1M

Select item 339281614.

Extracellular nicotinamide phosphoribosyltransferase (NAMPT/visfatin) inhibits insulin-like growth factor-1 signaling and proteoglycan synthesis in human articular chondrocytes

Raghunatha R Yammani, Richard F Loeser

Arthritis Res Ther. 2012; 14(1): R23. Published online 2012 Jan 30. doi: 10.1186/ar3705

PMCID:: PMC3392816

Abstract Article PDF–510K

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Visfatin Impairs Endothelium-Dependent Relaxation in Rat and Human Mesenteric Microvessels through Nicotinamide Phosphoribosyltransferase Activity

Susana Vallejo, Tania Romacho, Javier Angulo, Laura A. Villalobos, Elena Cercas, Alejandra Leivas, Elena Bermejo, Raffaele Carraro, Carlos F. Sánchez-Ferrer, Concepción Peiró

PLoS One. 2011; 6(11): e27299. Published online 2011 Nov 3. doi: 10.1371/journal.pone.0027299

PMCID:: PMC3207864

Abstract Article PDF–766K

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Leucocytes are a major source of circulating nicotinamide phosphoribosyltransferase (NAMPT)/pre-B cell colony (PBEF)/visfatin linking obesity and inflammation in humans

D. Friebe, M. Neef, J. Kratzsch, S. Erbs, K. Dittrich, A. Garten, S. Petzold-Quinque, S. Blüher, T. Reinehr, M. Stumvoll, M. Blüher, W. Kiess, A. Körner

Diabetologia. 2011; 54(5): 1200–1211. Published online 2011 Feb 6. doi: 10.1007/s00125-010-2042-z

PMCID:: PMC3071946

Abstract Article PDF–355K

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Nicotinamide phosphoribosyltransferase inhibits receptor activator of nuclear factor-κB ligand-induced osteoclast differentiation in vitro

Jong Min Baek, Sung-Jun Ahn, Yoon-Hee Cheon, Myeung Su Lee, Jaemin Oh, Ju-Young Kim

Mol Med Rep. 2017 Feb; 15(2): 784–792. Published online 2016 Dec 23. doi: 10.3892/mmr.2016.6069

PMCID:: PMC5364879

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Nampt/PBEF/Visfatin Upregulation in Colorectal Tumors, Mirrored in Normal Tissue and Whole Blood of Colorectal Cancer Patients, Is Associated with Metastasis, Hypoxia, IL1β, and Anemia

Katarzyna Neubauer, Iwona Bednarz Misa, Dorota Diakowska, Bartosz Kapturkiewicz, Andrzej Gamian, Malgorzata Krzystek-Korpacka

Biomed Res Int. 2015; 2015: 523930. Published online 2015 May 13. doi: 10.1155/2015/523930

PMCID:: PMC4444566

Abstract Article PDF–766K

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PBEF exerts a neuronal protection through its enzymatic activity and the reduction of mitochondrial dysfunction in in vitro ischemic models

Jing Bi, Hailong Li, Shui Qing Ye, Shinghua Ding

J Neurochem. Author manuscript; available in PMC 2013 Jan 1.

Published in final edited form as: J Neurochem. 2012 Jan; 120(2): 334–346. Published online 2011 Nov 24. doi: 10.1111/j.1471-4159.2011.07566.x

PMCID:: PMC3243794

Abstract Article PDF–2.7M

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Relationship between NAMPT/PBEF/visfatin and prognosis of patients with malignant tumors: a systematic review and meta-analysis

Chengjian Ji, Rong Cong, Yi Wang, Yamin Wang, Qijie Zhang, Xiang Zhou, Qianwei Xing, Ninghong Song

Ann Transl Med. 2019 Dec; 7(23): 785. doi: 10.21037/atm.2019.11.32

PMCID:: PMC6989992

Abstract Article PDF–4.4M

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PMC Images search for pre-B cell colony-enhancing factor,PBEF

Figure 1

PBEF stimulates expression and release of other cytokines. PBEF, pre-B-Cell colony enhancing factor; IL, interleukin, TGF-β1, transforming growth factor-1β; TNF-α, tumor necrosis factor-α; NFkB, nuclear factor kB; STAT3, signal transducer and activator of transcription 3; CCR-3, C-C chemokine receptor type 2;

Pre-B Cell Colony Enhancing Factor (PBEF), a Cytokine with Multiple Physiological Functions

Cytokine Growth Factor Rev. ;24(5):433-442.
Figure 5

Acute and chronic cardiovascular effects of visfatin. VEGF, vascular endothelial growth factor; MMP-2, matrix metalloproteinase-2; MMP-9, matrix metalloproteinase-9; PBEF, pre-B cell colony-enhancing factor I-R, ischemia-reperfusion.

Adipocytokines in Atherothrombosis: Focus on Platelets and Vascular Smooth Muscle Cells

Mediators Inflamm. 2010;2010:174341.
Figure 2

PBEF activates T cells, B cells and monocytes. PI3K, phosphoinosite 3-kinase; TNF-α, tumor necrosis factor-α; MCP-1, monocyte chemotactic protein-1.

Pre-B Cell Colony Enhancing Factor (PBEF), a Cytokine with Multiple Physiological Functions

Cytokine Growth Factor Rev. ;24(5):433-442.
Fig. 8.

Plasma inflammatory cytokines were assessed by Bio-Plex cytokine assay kit at R30 and R4h. A: IL-1β at R4h (*P < 0.01) was attenuated by VO (#P < 0.05). B: IL-10 at R4h (#P < 0.05) was further increased by VO (*P < 0.01). C: pre-B cell colony enhancing factor (PBEF) was elevated as early as R30 (*P < 0.01) and continued to increase by R4h (*P < 0.01). VO attenuated it at both R30 (*P < 0.01) and R4h (#P < 0.05). D–G: VO had no effect on IL-6, murine IL-8 (KC), TNF-α, and INFγ (P = not significant). Data presented are means ± SE of 5 mice.

A novel pharmacological strategy by PTEN inhibition for improving metabolic resuscitation and survival after mouse cardiac arrest

Am J Physiol Heart Circ Physiol. 2015 Jun 1;308(11):H1414-H1422.